Journal of Veterinary Medicine and Surgery 开放获取

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Absence of WDR13 in p53-Null Mice Increases Longevity

Arun Prakash Mishra*, Jyothi B Lakshmi

Absence of WDR13 is known to be involved in pancreatic, colon and uterine hyper proliferation. However, a recent study showed its anti-proliferative role liver regeneration in response to hepatotoxins. These findings intrigued to study the role of WDR13-null condition in Trp53 knockout mouse to study the tumor predisposition and survival. We report absence of Wdr13 in Trp53 null background alleviates the tumor load, in turn increasing total survival in mouse model.