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Analysis of Viral bacterial Co infection in Respiratory sampling Using Multiplex actual time PCR

Vijay Singh

Influenza and non-Influenza virus related respiratory tract infections are amongst the most common reasons reported for physician visits and hospitalizations, globally. The economic burden associated with these viral infections, within the United States, are upwards of $50 billion annually. Concomitant, or subsequent, co-infections of the respiratory tract by pneumonia-causing pathogenic bacteria, like Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus, are often observed in patients suffering from these respiratory viral infections and contribute to significant co-morbidity and mortality. In the present study, respiratory swabs from patients were tested for the presence of viral and bacterial pathogens, by Real-Time PCR, employing  the Thermo-Fisher Open Array® platform. Amongst the 5793 samples tested (Dec 2017-Dec 2018), 2357 (40.68%) tested positive for the presence of Influenza and Non-Influenza viral infections. Out of these positive  patient samples, 1175 (49.85%) also tested positive for the presence of one or more pneumonia-causing bacterial species.