美国药物输送和治疗杂志 开放获取

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Anti-Inflammatory Activity of Various Fractions of Methanolic Extract of Punica granatum rind with its Phytochemical Evaluation

Rahul Nainwani, Divya singh, Amit Gupta, Mohit Batra and Patel Hardik

Objective: To evaluate anti-inflammatory potential of rind extract of Punica granatum by in-vitro anti-inflammatory model and its phytochemical evaluation. Method: The fractionation of methanolic extract of Punica granatum rind was done using various solvents and evaluated for anti-inflammatory activity using in-vitro human red blood cell (HRBC) membrane stabilization method and its phytochemical study. Results: The in-vitro membrane stabilizing test showed that butanol, nhexane and aqueous extracts have potent anti-inflammatory activity which were 42.66%, 14.1% and 28% protection, respectively as compared to Standard drug. The potency of the rind extracts of PG were compared with standard diclofenac in stabilization test and which showed 81.76% protection in in-vitro HRBC membrane stabilization method. The extract showed the dose dependent anti-inflammatory activity. Conclusions: The present investigation has confirmed the antiinflammatory activity of fractions of methanolic extract of Punica granatum rind due to presence of alkaloids, steroids, terpinoids for the first time and provided the pharmacological evidence in the favour of traditional uses of Punica granatum as an anti-inflammatory agent.