Claude Flamand
Arboviral infections have become a significant public health problem worldwide and estimating their true burden represents a crucial issue but remains a difficult task. In French Guiana, the epidemiology of arboviral diseases has been marked by the occurrence several major dengue fever (DENV) outbreaks over the past few decades, recent emergences of Chikungunya (CHKV) and Zika virus (ZIKV) and the circulation of Mayaro virus (MAYV). To assess antibody seroprevalence against DENV, CHIKV, ZIKV, MAYV, a random 2-stage household cross-sectional serosurvey was conducted among the general population. We enrolled 2,697 individuals aged 2-75 years from June to October 2017. We performed detection of IgG antibodies using a multiplexed microsphere-based IgG immunoassay. Socio-economic, environmental data and exposure to mosquitoes were collected using a standardized questionnaire. The impact of cross-reactivity between same families of viruses was quantified combining seroneutralization tests and modeling approaches. Overall seroprevalence rates for DENV, CHIKV, ZIKV and MAYV were respectively 69.7% [66.2%-71.0%], 22.9% [20.3%-25.8%], 23.3% [20.9%-25.9%] and 2.9% [2.9%-3.1%]. The spatial distribution of seroprevalence rates for CHIKV, ZIKV antibodies differed from extrapolations obtained from routine surveillance systems and brings valuable information to assess the epidemic risk of future outbreaks.
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