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Bioadhesive Gel and Hydrogel Systems for Buccal Delivery of Ketoprofen: Preparation and In vitro Evaluation Studies

Mine Özyazıcı, Melike Fırlak, Sakine Tuncay Tanrıverdı, Seda Rençber, Sinem Yaprak Karavana and Memet Vezir Kahraman

Introduction: The studies are focused on buccal system due to advantages such as avoidance of the hepatic first-pass metabolism and better patient medication compliance. Ketoprofen (KP) which is a non-steroidal antiinflammatory, analgesic and antipyretic agent that used as an active substance. Method: Buccal bioadhesive gels (BG) and bioadhesive hydrogels (BHG) with KP were prepared with Carbopol (CP) 940 and CP 934 as polymers. BG were characterized by determination of rheological properties, mechanical stress and mucoadhesive properties. And also BHG were tested for tensile strength and mucoadhesive properties. The release studies through dialysis bags were performed for all formulations. Results: BHG for buccal application were formulated by photopolymerization technique for the first time in this study. According to comparing obtained results, it can be suggested that BHG can be offered as promising dosage form for the buccal application.