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Complex Behavior of Bile Salts (SC and SDC) at Various Temperatures under the Influence of Tricyclic Antidepressant Drug (Imipramine) in Aqueous Solution

Santosh Kumar Sar

Objective: The present method was based on the effect of bile salt (Sodium Cholate (SC) and Sodium Deoxycholate (SDC)) on the dissolution of Antidepressant drug like Imipramine. SC and SDC is a type of anionic surfactants form mixed micelle with Imipramine and influence its rate of dissolution. The micellization behaviour of binary anionic bile salt surfactant mixtures was investigated by conductivity method and various thermodynamical parameters are calculated. The results of the study have been analyzed by using Clint’s, Rubingh’s, and Motomura’s theories for mixed binary systems.

Method: The Critical Micelle Concentration (CMC) of the binary mixtures (Bile salt and Drugs) were studied using conductivity measurements, at different mole fractions and different temperatures.

Results: The micellization behaviour of binary anionic surfactant and drug mixtures was investigated by conductivity CMC, extent of counter ion binding (α), thermodynamic parameters (ΔG°m, ΔH°m, ΔS°m) and various parameters like cmcid, xid, X1 and the β parameter for micellization process have been reported and discussed.

Conclusion: The thermodynamic parameters of the process of micellization have been calculated for each system. ΔG°m is negative and becomes less negative with increase in concentration. This suggests the micellization formation is becomes less spontaneous with increasing temperatures. The entropy of micellization is positive indicated that the micellization process is somewhat entropy dominated.