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Complexation: Effect of Metal on Microbiological Activity of Sulfanilamide Derivatives

Pratik R. Chaudhary and Dr. Dhrubo Jyoti Sen

Resistance strain which outgrows current therapeutics. As new drug development either against resistance strain or any new disease is neither easier nor cheap. Modification of the available entity generally called “sulfonamide” with metal. Sulphonamides and metal duos are promising for their antimicrobial activity. Sulfanilamide metal complexes were synthesized. Coordination complexes of sulfonamide with metal such as Copper, Barium, Zinc, Ferric, Aluminum, Cadmium, Manganese, Magnesium and Calcium were prepared by complexation reaction under stirring and control environmental conditions. The purity of complexes was checked by TLC monitoring and all synthesized complexes were characterized using I.R., Mass, Atomic Absorption Spectroscopy. The antibacterial activity of synthesized complex was tested by Agar plate method.