欧洲实验生物学杂志 开放获取

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Design, docking and synthesis of some 6-benzimidazoyl pyrans and screening of their anti tubercular activity

Francis M Saleshier, Suresh.S, Anitha .N, JubinaKarim and Madhu.C.Divakar

In continuation of our research for new antitubercular agents, a series of substituted benzimidazoles with pyran were synthesized and screened for their anti tubercular activity by Alamar Blue assay method. The structure and purity of all the compounds were confirmed on the basis of chromatographic data, elemental analysis and spectral studies. All the synthesized compounds were found to be active against Mycobacterium tuberculosis H37Rv at 10 and 100 mcg/ml concentrations. But the compounds C-1, C-3, and C-5 showed effective antitubercular activity, even at 1mcg/ml concentration. The 2-methoxy phenyl derivative exhibited better anti tubercular activity compared to the 4-methoxy phenyl compound. Molecular docking studies were also done subsequently, using target, enoyl reductase enzyme (InhA) to find the structural requirement for activity for these series of compounds.