Maidul Islam
In present day the pandemic character of Novel Corona Virus Covid-19 become the most life threatening problem for human health. Till date around 6.5 million of people were affected and 0.4 million were died of this. In spite of all types of precaution the rate of spreading increasing day after day and if it could not be ceased, whole human being in world will cease to exist. Remdesivir is an antiviral drug that was developed to block infection with related coronaviruses and even Ebola. It is one of the drugs the WHO is helping to investigate. It works against SARS-CoV-2 in cells in a dish in a lab as well as in mice infected with the virus. Remdesivir specifically targets key viral proteins involved in making new copies of the virus and prevents them from working. Due to the bulkier structure, Remdesivir violets Lipinski rule (MW>500 and No of H-bond accepters >10), shows very low GI track absorption and bioavailability (0.17). In this work, I tried to investigate the structural aspects of Remdesivir for the binding with viral protein and from the availed data tried to design (Insilico) a newer molecules which binds more effectively with the protein. My work will helpful to enrich the data base for the develop more efficient drug than Remdesivir.
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