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Docking studies on fungal lectin for inducing tumor necrosis factor related apoptosis inducing ligand-receptor 2 (TRAIL-R2): Using Hex

Sathishkumar Arumugam and Kalaiselvam Murugiyan

Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL) is member of cytokines which induce apoptosis only on cancer cells, by binding with their receptors called TRAIL-R1 and TRAIL-R2. But almost all cancerous cells are resistance to TRAIL mediated apoptosis. Here we described the docking of fungal derived lectins for induction of TRAIL-R2. Four fungal lectins Sclerotinia sclerotiorum (SSL), Flammulia velutipes (FVL), Psathyrella velutina (PVL), Xerocomus chrysenteron (XCL) and TRAIL-R2 structure were derived from Protein Data Bank. The binding energy of fungal derived Lectins with TRAIL-R2 were estimated by using Hex 6.0 docking software. All fungal derived Lectin peptides were showed good binding energy, among them XCL showed excellent binding energy (-539.72). Further in vitro and in vivo study is needed to confirm the up regulation of TRAIL-R2, decipher to TRAIL