妇产科病例报告 开放获取

抽象的

Early Pregnancy Metabolism and the Development of Systolic Blood Pressure

Romy Gaillard*

The development of blood pressure has a significant impact on the aetiology and prognosis of gestational hypertension diseases. The study of new metabolites that might be used to predict gestational hypertensive diseases and reveal underlying metabolic pathways in the genesis of hypertension in pregnancy are both possible outcomes of metabolomics. Liquid chromatography—mass spectrometry was used to measure the blood concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines in early pregnancy in a population-based, prospective cohort research involving 803 pregnant women. Every trimester of pregnancy saw blood pressure readings. Medical records were used to gather data on illnesses that cause gestational hypertension. Throughout pregnancy, increased systolic blood pressure was linked to higher individual metabolite concentrations.