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質構儀評估不同聚合物與黏膜組織的黏膜黏附性能

法特馬努爾·圖古-德米羅斯

Mucoadhesive polymers are a gathering of materials utilized in various pharmaceutical frameworks. They are characterized as hydrophilic macromolecules, which contain various practical natural gatherings ready to build up associations with mucosal films. These polymers can be characterized by their communications with the mucosa. Non-covalent bonds accepted to improve mucoadhesion incorporate hydrogen-holding, hydrophobic cooperations, and electrostatic connections. Mucoadhesive polymers might be cationic, anionic, or non-ionic. Anionic polymers, for example, poly(acrylic corrosive) derivates, are accepted to frame hydrogen bonds beneath their pKa between their carboxylic gatherings and the hydroxyl gatherings of the bodily fluid glycoprotein. It has additionally been recommended that particle dipole communications may happen when in the carboxylate. Also, poly derivates might be joined in arrangement with thermoresponsive polymers, as poloxamer 407 (P407), to upgrade maintenance. Thermoresponsive polymers change from a fluid to a gooey gel over a basic temperature, taking into consideration section through an utensil before thickening upon application to the body. The component of mucoadhesion is commonly separated into two stages: the contact stage and the union stage. The principal stage is described by the contact between the mucoadhesive and the bodily fluid film, with spreading and expanding of the definition, starting its profound contact with the bodily fluid layer. In the union advance, the mucoadhesive materials are enacted by the nearness of dampness. Dampness plasticizes the framework, permitting the mucoadhesive particles to split free and to connect up by frail vander Waals and hydrogen bonds. Mucosal surfaces spread the nasal, visual, buccal, rectal, vaginal, and gastrointestinal zones among different pieces of the body. Medications might be directed to these destinations for nearby impact, and their high porousness makes them appealing for fundamental medication conveyance. Be that as it may, the regular freedom instruments from these destinations limit living arrangement time, diminishing medication assimilation or span of neighborhood impact. So as to beat these weaknesses, "mucoadhesive" frameworks have been created, which hold fast to mucosal films through an assortment of alluring physicochemical associations, improving maintenance, and in this manner the adequacy of medications Mucoadhesion is the capacity of materials to stick to mucosal layers in the human body and give a transitory maintenance. This property has been broadly used to create polymeric dose structures for buccal, oral, nasal, visual and vaginal medication conveyance. Incredible mucoadhesive properties are run of the mill for hydrophilic polymers having charged gatherings and additionally non�ionic utilitarian gatherings fit for shaping hydrogen bonds with mucosal surfaces. This component article thinks about late advances in the investigation of mucoadhesion and mucoadhesive polymers. It gives a diagram on the structure of mucosal films, properties of bodily fluid gels and the idea of mucoadhesion. Essential destinations behind the utilization of mucoadhesive medication conveyance gadgets are to delay their private time at the specific site to make them target explicit, and to improve the medication ingestion process. Along these lines, the estimation of mucoadhesivity is a critical advance to plan the mucoadhesive medication conveyance frameworks. The procedure of the utilization of mucoadhesive polymeric materials to improve the adequacy of remedial medicines has been presented as some time in the past and the methodology is still of an extraordinary enthusiasm for the field of pharmaceutical sciences. In vitro or ex vivo procedures are significant in the exhibition testing of mucoadhesive medication conveyance frameworks and are savvy in choosing proficient frameworks when contrasted and in vivo strategies. These techniques can assess mucoadhesive details, without utilizing creature models, and may offer robotic comprehension of mucoadhesion. Various strategies have been created to survey and comprehend the mucoadhesion of medication conveyance frameworks. The advancement of new strategies ought to be approved by correlation with a highest quality level in vitro method, or in vivo execution. New strategies to examine the mucoadhesive profile of semisolid polymer frameworks are commonly evolved in-house on bespoke hardware, and have not experienced approval, which stresses the significance of normalized methods. Besides, every measurements structure may require diverse trial conditions and examination may just be conceivable inside dose structure types. The separation power technique (otherwise called the ductile strategy) is the most broadly utilized technique to explore glue associations between a mucosal film (or other substrate) and a detailing. This strategy can be utilized for strong and semisolid measurement structures and it is realized that instrumental boundaries and analysis configuration impact test results. Different strategies, for example, the rheological strategy, can bring about various reactions and translations relying upon the examination type utilized. In this way, it is imperative to comprehend the factors of the technique for mucoadhesion testing, taking into account that normalized strategies have been required.

黏膜黏附是一個令人難以置信的過程，人們提出了各種推測來澄清所討論的儀器。這些是潤濕假說、擴散假說、斷裂假說、電子假說、吸附假說。正在研究黏膜黏附運輸框架，以將動態專家限制在特定區域/地點。聚合物在建構此類框架方面發揮重要作用，以便在理想區域建立動態專家的居住時間。黏膜黏附聚合物是水溶性和水不溶性聚合物。牢牢黏附在黏蛋白上皮表面的黏膜黏附聚合物可以有效地分為三類：

1.聚合物在水中凝固後會變得黏稠，其黏膜黏附力歸功於韌性。

2. 聚合物透過模糊的非共價締合，本質上是靜電的

3. 聚合物對瓷磚自身表面上的明確受體位點感到困惑。

三種聚合物類型中的每一種都可用於藥物傳輸。在這項研究的背景下，解決了用各種聚合物建立的凝膠定義對各種黏膜組織的黏膜黏附特性。作為聚合物，使用了八種不同的聚合物； Kitosan M、Kitosan H、HPMC K15M、HPMC K100M、瓜爾膠 H、瓜爾膠 S、Carbopol® 974 P 和 Policarbophil® AA-1。利用九種不同的牛樣黏膜組織（陰道、鼻、頰、腸、結腸、胃、子宮和喉嚨）對所排列的凝膠進行黏膜黏附研究。 TA.XT。此外，質地分析儀也用於測量黏膜黏附凝膠定義與黏膜分離的能力以及黏膜黏附過程。此外，將脂質體作為微粒框架添加到凝膠細節中，以觀察鍵結如何受到影響。就整體結果而言，與其他聚合物相比，Kitosan H 和瓜爾膠 H 被認為是最佳的黏膜黏附性能