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Gynecologic Tumors: Molecular Oncology

Zyan Hadhi*, Umar Abdullah

Both oncologists and pathologists have acknowledged that the broad histologic classifications, particularly for ovarian and endometrial carcinomas, do not consistently separate groups with comparable clinical trajectories or therapeutic response patterns. When the findings from the Cancer Genome Atlas (TCGA) project were released during the previous decade, a paradigm shift was triggered. Instead of the two subtypes proposed by Bokhman in the 1970s, extensive genomic profiling data from TCGA has revealed that there are four molecular subgroups of endometrioid carcinomas.