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Hepatic Glucagon Receptor (GCGR) Signaling to Drive Alpha Cell Hyperproliferation and Pancreatic Neuroendocrine Tumor Formation.

Dantas M. Alva

Hypoglycemia causes the pancreatic alpha cells to produce glucagon, which promotes hepatic glucose synthesis. Deregulated glucagon secretion is linked to type 2 diabetes, and elevated glucagon levels contribute to diabetic hyperglycemia. Endocrine cells of the pancreatic islets are known as alpha cells (α-cells). They make up to 20% of human islet cells, which synthesize and secrete the peptide hormone glucagon, which raises blood glucose levels.