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Homology Modeling of Mouse orphan G-protein coupled receptors Q99MX9 and G2A

Aditya Sood

GPCRs are fundamental membrane proteins and they are called as G-Protein Couple Receptors. They are rooted in the cell surface that conveys signals to cell, also known as seven membrane domain receptors. If these receptors do not role correctly, then this may lead to numerous diseases. Orphan Receptors lack endogenous ligands and their particular purpose is not known. Presently there are few ideal structures in databank for following structural biology studies but no orphan GPCR coordinates exist in protein data bank. The aim for gaining appropriate structures for these proteins is to deorphanize them and to study biological applications. There are numerous GPCRs whose 3D structures are obtainable, using those structures as templates, computer based homology modeling method can be used to presume 3D structures of numerous proteins by means of their amino acid sequence. In this study, we have modeled Q99MX9_MOUSE and G2A_ MOUSE, class an orphan GPCRs whose 3D structures have been assumed using Swiss pdb Viewer; the PDB templates used for these orphan GPCRs are 2RH1 and 3UON correspondingly. Based on the outcome of homology modeling of these proteins, their structure has been acquired and their purpose can be presumed on the basis of structural and sequence similarity to known GPCRs. As the structure has been assumed for these GPCRs probable ligands and similarities can be anticipated.