阿邁勒·薩巴希
許多標記試劑在經濟上可以用於評估必需醇；儘管如此，這些試劑也有一些缺點，例如有害、缺乏敏感性和選擇性、溶解度低以及成本昂貴。利用螢光雜環混合物作為標記已成為科學領域的新興領域。吡唑啉是一種雜環合成化合物，原子配方為C3H6N2。吡唑啉是一種著名的雜環化合物，具有令人著迷的光物理特性，使其有資格用於生物有機原子的檢測和成像。吡唑啉是一種重要的五元氮雜環，已被廣泛研究。環非常穩定，引起了科學專家在環中做不同的輔助品種。這透過各種藥理學研究推動了特定吡唑啉的發展。緩解、止痛、抗菌、抗癌、提神等。吡唑啉，在不同的五元雜環化合物下屬中，由於其不同的藥理學作用而引起人們的關注。吡唑啉是一種五元雜環，環內有兩個連續的氮顆粒，僅具有一個環內雙鍵，並且是自然界中必需的。這些顏色的應用涵蓋了許多領域，從光動力疾病治療、自然光輻射二極體到線束增亮和照明。無論如何，最近它已被評估為氨基酸和突觸的前段衍生化的潛在可能性。這項研究背後的動機是評估最近加入的吡唑啉, 4-(1-(4-三氟甲基)苯基)- 4, 5-二氫-3-(萘基)- 1H-吡唑-5-基)苯甲酸的充足性腐蝕性（TFNPB）作為必需醇的名稱，並建立了用於評估各種晶格中的這些分析物的預段衍生化技術。
The pyrazoline core is an omnipresent element of different mixes having numerous pharmacological and physiological exercises and hence they are valuable materials in tranquilize inquire about. It was accounted for in the writing that distinctive subbed 2-pyrazolines have antimicrobial, calming, pain relieving, antipyretic, stimulant, antitubercular, antiamoebic, anthelmintic, anticonvulsant, antihypertensive, antidiabetic, antitumor, hostile to HIV, neighborhood sedative, cancer prevention agent, insecticidal and sedating exercises Compounds with alkane and ester bunches at pyrazolinyl spiros were examined for their antibacterial exercises against both erythromycin-defenseless and erythromycin-safe microscopic organisms. All the subsidiaries were found to have preferred antibacterial exercises over erythromycin An and clathriamycin against S.aureus strains, and with practically proportional bioactivities against S.pneumonia and H.influenza strains. Among the C-12 pyrazolinyl spiro ketolides, mixes with ester substituents showed preferable antibacterial exercises over those of mixes.
Fluorescence finders are likely the most touchy among the current present day HPLC locators. It is conceivable to recognize even a nearness of a solitary analyte atom in the stream cell. Ordinarily, fluorescence affectability is 10 - multiple times higher than that of the UV identifier for solid UV engrossing materials. Fluorescence locators are unmistakable and specific among the others optical identifiers. This is ordinarily utilized as a bit of leeway in the estimation of explicit fluorescent species in tests. At the point when mixes having explicit utilitarian gatherings are energized by shorter frequency vitality and produce higher frequency radiation which called fluorescence. As a rule, the discharge is estimated at right edges to the excitation. Generally about 15% of all mixes have a characteristic fluorescence. The nearness of conjugated pi-electrons particularly in the fragrant segments gives the most serious fluorescent movement. Likewise, aliphatic and alicyclic mixes with carbonyl gatherings and mixes with profoundly conjugated twofold bonds fluoresce, however normally to a lesser degree. Most unsubstituted fragrant hydrocarbons fluoresce with quantum yeld expanding with the quantity of rings, their level of buildup and their basic unbending nature.
Fluorescence force relies upon both the excitation and outflow frequency, permitting specifically distinguish a few segments while smothering the discharge of others. The recognition of any segment fundamentally relies upon the picked frequency and in the event that one part could be identified at 280 ex and 340 em., another could be missed. A large portion of the advanced finders permit quick switch of the excitation and discharge frequency, which offer the likelihood to distinguish all part in the blend.
Methodology & Theoretical Orientation:
TFNPB was blended by the regular technique, which includes two stages, an aldol buildup response between acetyl-naphthalene and 4-formylbenzoic corrosive followed by Michael expansion of the phenyl-hydrazine. The photophysical properties including assimilation, outflow, and lifetime estimations have been concentrated in various solvents. Essential alcohols were then derivatized by this reagent, and LC-MS was utilized to survey the delivered subordinates. The derivatization system was streamlined, and the test of alcohols by this strategy was approved. Fluid chromatography–mass spectrometry (LC-MS) is a logical science strategy that consolidates the physical partition capacities of fluid chromatography (or HPLC) with the mass investigation abilities of mass spectrometry (MS). Coupled chromatography - MS frameworks are famous in substance examination in light of the fact that the individual capacities of every procedure are upgraded synergistically. While fluid chromatography isolates blends with different segments, mass spectrometry gives auxiliary character of the individual segments with high atomic explicitness and discovery affectability. This pair strategy can be utilized to dissect biochemical, natural, and inorganic mixes normally found in complex examples of ecological and organic starting point.
Notwithstanding the fluid chromatography and mass spectrometry gadgets, a LC-MS framework contains an interface that effectively moves the isolated parts from the LC section into the MS particle source. The interface is vital in light of the fact that the LC and MS gadgets are on a very basic level inconsistent. While the portable stage in a LC framework is a pressurized fluid, the MS analyzers usually work under high vacuum with 10−6 torr/10−7 Hg. In this way, it is beyond the realm of imagination to straightforwardly siphon the eluate from the LC section into the MS source. Generally, the interface is a precisely straightforward piece of the LC-MS framework that moves the greatest measure of analyte, evacuates a critical segment of the portable stage utilized in LC and jam the substance personality of the chromatography items (artificially inactive). As a prerequisite, the interface ought not meddle with the ionizing proficiency and vacuum states of the MS framework.
Findings:
TFNPB 顯示出優異的光物理特性，包括高螢光功率和量子產率。它在乙腈中的 460 nm 處的明顯區域中放電。它用於在低溫和短響應時間內快速輔助羥基束。使用 75% ACN 水溶液，液體下屬在 C8 切片上顯示出非常孤立的固體尖峰（目標 μ1.5）。交付的子公司室溫穩定1個多月。四種醇在 1.25-94 μmol L-1 範圍內獲得了良好的直接聯繫（R2≥0.991）。所有合法性數據均已確定，所創建的技術已獲批准用於精油的定量研究。
傳：
Amal Al Sabahi 於 1996 年在蘇丹卡布斯大學 (SQU) 獲得科學教育學士學位，並於 2003 年在 SQU 理學院化學系獲得化學碩士學位。她擔任化學教師十年，教育研究員六年。她在 SQU 擔任實驗室講師三年。
English 
Spanish 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi