莫妮卡·蘇萊科娃
介紹：
以商品名 Aleve 銷售的萘普生是一種非類固醇鎮靜藥物 (NSAID)，用於治療疼痛、月經問題、燃燒性疾病，如類風濕性關節炎和發燒。它是透過嘴巴攝取的。它可以透過快速和延遲放電定義進行存取。撞擊在一小時內開始，持續長達十二小時。萘普生是一種非選擇性 COX 抑制劑。它屬於丙酸腐蝕類藥物。作為一種非類固醇抗發炎藥，萘普生似乎透過減少稱為前列腺素的刺激性仲裁者的產生來發揮其鎮靜作用。它被肝臟加工成惰性代謝物。萘普生的臨床用途是透過其作為緩解化合物的活性成分來確定的。萘普生用於治療各種因不必要的加重而引起的刺激性病症和症狀，例如疼痛和發燒。萘普生的活性工具與其他非類固醇抗發炎藥物相似，被認為與環加氧酶運動的阻礙有關。 COX-1 的阻礙被認為與胃腸道和腎臟毒性有關，而 COX-2 的抑制則可減輕運動。萘普生用於緩解不同情況引起的疼痛，例如偏頭痛、肌肉疼痛、肌腱炎、牙齒疼痛和月經痙攣。它還可以減輕關節發炎、滑囊炎和痛風發作引起的疼痛、腫脹和關節僵硬。萘普生是 CYP1A2 和 CYP2C9 的次要受質。它在肝臟中被廣泛加工成 6-O-去甲基萘普生，母體藥物和去甲基代謝物都進一步消化為其特定的酰基葡萄醣醛酸結合的代謝物。兩項臨床初步研究表明，萘普生是在口腔組織後 2-4 小時內達到最高血漿固定的理想機會，但萘普生鈉在 1-2 小時內到達最高血漿焦點。
方法：
Mesoporous silica SBA-15 was set up to assess its application as naproxen tranquilize conveyance framework. A tale SBA-15 (2.5N-SBA-15) with pores infiltrating into the silica dividers has been orchestrated with amino-finished hyperbranched polyamide (AEHPA) and P123 as co-layouts. This tale layout strategy effectively engraves mesoporous depressions into the silica structure. The acquired composites are utilized as a Co (15 wt%) impetus support for Fischer–Tropsch Synthesis (FTS). The reactant movement and item selectivity are essentially affected by the help structure. Contrasted and the ordinary 15Co/SBA-15 impetus, the 15Co/2.5N-SBA-15 impetus with an infiltrating pore structure shows improved reducibility of cobalt species, prompting better synergist properties as for CO action and C5+ selectivity during the FTS response.
The measure of naproxen discharged from the pores of mesoporous silica SBA-15 into the arrangements was dictated by the technique for an opposite stage elite fluid chromatography (RP-HPLC). The detachment component in turned around stage chromatography relies upon the hydrophobic restricting connection between the solute particle in the portable stage and the immobilized hydrophobic ligand, for example the fixed stage. The real idea of the hydrophobic restricting communication itself involves warmed discussion however the tried and true way of thinking expect the coupling association to be the consequence of a positive entropy impact. The underlying portable stage restricting conditions utilized in switched stage chromatography are basically watery which shows a high level of sorted out water structure encompassing both the solute particle and the immobilized ligand. As solute ties to the immobilized hydrophobic ligand, the hydrophobic region presented to the dissolvable is limited. Subsequently, the level of sorted out water structure is reduced with a comparing ideal increment in framework entropy. Along these lines, it is beneficial from a vitality perspective for the hydrophobic moieties. Turned around stage chromatography is an adsorptive procedure by exploratory plan, which depends on a parceling component to impact division. The solute particles parcel (for example a harmony is set up) between the portable stage and the fixed stage. The dissemination of the solute between the two stages relies upon the coupling properties of the medium, the hydrophobicity of the solute and the sythesis of the portable stage. At first, test conditions are intended to support adsorption of the solute from the versatile stage to the fixed stage. Along these lines, the versatile stage sythesis is changed to support desorption of the solute from the fixed stage once again into the portable stage. For this situation, adsorption is viewed as the outrageous balance state where the appropriation of solute atoms is basically 100% in the fixed stage. Then again, desorption is an extraordinary balance state where the solute is basically 100% appropriated in the versatile stage.
SBA-15 having 3-aminoprophyl-, methyl-, fenyl-and cyclohexyl-surface gatherings was effectively arranged by the joining of SBA-15 with the comparing alkoxysilanes. The arrival of the medication was acted in two unique media, in a recreated body liquid (pH 7.40) and in a reproduced gastric liquid (pH 2.06). The HPLC framework Dionex Ultimate 3000 RS (Thermo Fisher Scientific, Germany) comprised of a quaternary siphon, a degasser, a mechanized injector, a segment broiler and a diode exhibit identifier DAD. HPLC framework was utilized, with fixed stage ODS Hypersil C18 section (150x4.6 mm, 3 μm).
Results and Discussion:
為了確定萘普生的集中度，根據萘普生不同會聚點的五種排列建立了調整彎道。線性度是透過每個聚焦步驟的三次重新雜湊估計來控制的。乙腈和水 (55:45，v/v) 的混合物與正磷酸腐蝕劑平衡至 pH 3，被選為最佳通用階段。流速為 1 mL/min，發現頻率為 229 nm。在色譜分離過程中，攜帶式載物台保持等度。
結論：
設定了溶解度檢查的起始色譜條件，並進行了各種準備工作，以確保萘普生能夠以極高的對稱性洗脫。 ODS Hypersil C18 切片（150x4.6 mm，3μm）和流速 1 ml/min，發現頻率 229nm，切片溫度 25℃，稀釋劑乙腈和水（55:45，v/v）條件被確定為簡化技術。透過多次注入標準來濃縮框架適當性參數，結果完全低於確認措施。線性研究被視為 R2 值被發現為 0.999。透過利用上述策略對所顯示的定義進行檢查，99.7% 可用。
傳
Monika Sulekova 已在斯洛伐克科希策的 Pavol Josef Safarik 大學畢業。大學學習期間，她在德國耶拿弗里德里希席勒大學學習了半年分析化學。目前，她在斯洛伐克科希策獸醫藥學大學擔任教師，同時也是不同官能基修飾的介孔二氧化矽中藥物解吸領域的研究員，以及透過化學方法測定藥品中合成染料的領域。法。
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