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Indoxacarb induces liver oxidative stress in Swiss Albino Mice

Tulasigiriyappa.Y. Mudaraddi, Rajeev. R. Potadar and Basappa. B. Kaliwal

Indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4-(trifluoromethoxy) phenyl]amino]carbonyl] indeno[1,2-e][1,3,4]oxadiazine-4a(3H) carboxylate, is a pyrazoline broad spectrum insecticide. The indoxacarb containing technical formulation was evaluated for its effects on the liver oxidative stress products and enzymes in male albino mice. Normal Swiss albino mice of 90 days old weighing about 25-30g were used in the experiment. The mice were administered with 6, 12, 18, and 24 mg/kg body wt indoxacarb for 30 days. The mice administered with distilled water were served as control and mice were sacrificed on day 31^st or 24 hours after the terminal exposure. Liver dissected out were freed from adherent tissue and weighed to nearest milligram. Liver oxidative stress byproducts of Lipid (Malonaldehyde) and protein (Protein carbonyl) contents were increased where as GSH (Glutathione) and ascorbic acid contents were decreased in mice treated with 18 and 24 mg/kg/day indoxacarb. In mice treated with 18 and 24 mg/kg/day of indoxacarb showed increase in SOD (Superoxide dismutase), Catalase and GST (Gluthathione-s-transferase). However, there was no change in the oxidative stress byproducts and enzymes in the mice treated with 6 and 12 mg/kg/day indoxacarb. The results of the present study suggest that chronic exposure to indoxacarb insecticide has deleterious effect on liver.