Journal of Neuro-Oncology and Neuroscience 开放获取

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Insomnia, a possible cause of Glioblastoma Multiforme (GBM); traditional medicine Kava Kava, a potential treatment for GBM

Ajay Samuel

In future and current aspects, more psychologically stressed people emerge from psychological disorder (insomnia) because of technological development and its addiction towards it. Cancer is the most aggressive disease which changes the biochemical reactions in the entire system and leads to mortality. Glioblastoma Multiforme (GBM) is the most lethal among all the brain tumors. Among 23,800 adults diagnosed for primary cancerous tumors of brain and spinal cord in 2017, 85-90% were accounted for brain tumor in USA and in 2500 children every year in India. This cancer is generally caused by multiple genes, multiple mutations and patients who were diagnosed for cancer develop psychological stress that leads to metastasis and cause secondary tumor. It is hypothesized that the chronic psychological stress induced by insomnia, which is caused by MEIS1 gene up-regulation, is responsible for GBM through manipulation of regulatory hormones and multiple onco-gene mutation. The traditional medicine Kava Kava may be used for treatment of GBM by counteracting the effects of stress.