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Investigation toxicity properties of zinc oxide nanoparticles on liver enzymes in male rat

Mohamad Fazilati

The toxicity Properties of Zinc Oxide Nanoparticles on Liver Enzymes (ALT, ALP and AST) in Male Rat was investigated. Characterization and morphological properties of Zinc Oxide nanoparticles was performed by means of X-ray diffraction (XRD) transmission electron microscopy (TEM), Scanning electron microscopy (SEM) and UV– visible (UV-VIS) spectrophotometer. Experimental studies were performed on 40 male rats that used for treatment with ZnO Nps. The results showed that activity of ALT enzyme Increased and compare to the control group in the second, third and fourth groups that received 50ppm, 100ppm and 200ppm nanoparticles respectively is significant from the statistical point (p˂0/05); activity of AST enzyme Increased in all groups. This increase compare to the control group in the fourth group that received 200ppm nanoparticles is significant from the statistical point (p˂0/05) and also activity of ALP enzyme Increased in all groups (Figure 6). This increase compare to the control group in the third and fourth groups that received 100ppm and 200ppm nanoparticles respectively is significant from the statistical point (p˂0/05).