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Polypyrrole-Cerium Oxide Nano Composite Glassy Carbon Platform for the Quantification of Torsemide

Archana Pawaiya1, Nimisha Jadon2 and Rajeev Jain1*

Present communication reports, fabrication of a novel polymer film of polypyrrole (PPy)-cerium oxide (CeO2) nano composite by chemical polymerization on a glassy carbon electrode (GCE), and thus developed sensor was applied for the quantification of Torsemide drug. The fabricated nano composite was characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Under optimized conditions, the anodic peak currents of Torsemide drug increased linearly with increase in concentration in the range of 100 ng/mL-6400 ng/mL. The prepared sensor showed good detection limit (33.85 ng/mL) and limit of quantification (102.58 ng/mL) sensitivity and repeatability. The proposed voltammetric sensor was also applied for the quantification of Torsemide in pharmaceutical formulation.