欧洲实验生物学杂志 开放获取

抽象的

PPAR-γ down regulation in 3t3l1 adipocytes by Solanum xanthocarpum Schrad & Wendl

Anitha Mary Mathews and Christina A. J. M.

Adipogenesis is a multistep process involving a number of transcription factors and cell cycle proteins that regulate gene expression leading to adipocyte development.PPARs are ligand activated and ligand binding nuclear receptors that respond to exogenous and endogenous ligand .They act by modulating genes related to lipid, insulin and glucose homeostasis. Solanum xanthocarpum is a plant with proven anti diabetic efficacy since it was found to possess and found to promote GLUT-4 uptake in L6 skeletal muscle cell lines and 3T3 L1 cell lines. The present study was aimed at examining its anti-dyslipedimic potential in T2DM.The results showed that an ethanolic extract of the plant Solanum xanthocarpum (SXA) in the dose of 100 μg/ml produced down-regulation of PPAR γ gene expression in 3T3L1 adipocytes reflecting its potential as an anti dyslipedimic agent.