Pallavi A. Patil, A.R. Umarkar, M.M. Bari and S.D. Barhate
Objective: A Stability indicating Reverse-Phase liquid chromatographic method for the simultaneous estimation of Drotaverine HCl and Mefenamic acid was developed.
Method: The chromatographic assay involves the use of Hi Q C-18 W (5μm column with a simple mobile phase containing 80:20% v/v of methanol & HPLC Grade water (0.1% triethylamine at pH 3) with flow rate of 1.0mL/min with UV detection at wavelength of 250 nm.
Result: The method showed good linearity in the concentration range of 2-10 μg/mL for Drotaverine Hcl and 6-30 μg/mL for Mefenamic Acid.
Conclusion: The developed method was successfully validated as per the ICH guidelines. The stability indicating capacity was also tested and successfully applied to marketed formulation.
English 
Spanish 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi