V. Benberin, N. Seidalin, N. Shanazarov, T. Voshchenkova, D. Babenko, A. Sibagatova
Statement of the Problem. The incidence of prostate cancer (PCa) due to increased life expectancy is steadily increasing.
Currently, a list of polymorphisms associated with the risk of tumors, their course and treatment response has been determined, but there is no convincing evidence for their clinical use.
Objective is to study the frequency of occurrence of polymorphisms in healthy men and patients with prostate cancer in the
Kazakh population.
Materials and methods. Two groups of Kazakh - patients with prostate cancer (n = 480) and control (n = 479) were recruited during 2017-2019. DNA from blood samples were genotyped with 120 SNPs chip using qPCR (QuantStudio 12K, ThermoFisher). Genotype annotation was performed with ThermoFisher cloup.
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