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The Potential of Non-Invasive Biochemical Testing Late Post-transplant in Prediction of Declining Kidney Allograft Function

Trailin A* and Nykonenko O

Identification of kidney transplant recipients at risk for allograft failure late posttransplant is an unmet demand. Our aim was to determine the capacity of serum beta-2- microglobulin (2MG), serum and urinary interleukins (IL-2, IL-10 and IL-8) and enzymes (γ-glutamyl transpeptidase, alkaline phosphatase, alanine aminotransferase [ALT], aspartate aminotransferase [AST], and N-acetyl-β-Dhexosaminidase [NAG]) in the late posttransplant period to predict a deterioration of kidney allograft function. Several non-invasive biomarkers predicted certain (serum 2MG, urinary IL-2 and AST), and rapid (urinary IL-2 and AST) drop of glomerular filtration rate over two years. We are standing on underestimated potential of non-invasive biochemical testing in kidney transplant setting.