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Three Cases of Congenital Anomalies U2bC2V1 with different Reproductive Outcomes: Is it Cause of Infertility?

Olga Triantafyllidou1, Maria Papageorgiou1, Panagiotis Christopoulos1, Stavroula Kastora2*, Emmanouil Kalampokas1, Theodoros Kalampokas1, Nikos Vlahos1

Background: Congenital uterine anomalies (CUAs) consist structural disorders of the female genital tract due to abnormal fusion or resorption of the Müllerian ducts. The prevalence of CUAs is 5.5% in the general population, 8.0% in infertile women and 13.3% in women with a history of miscarriage.

Results: We present three cases of women with complex genital tract anomalies (U2bC2V1), including cervical duplication and vaginal septum with different reproductive outcomes.

Conclusion: A complete uterine septum with double functional cervix may have a wide spectrum of reproductive outcomes. We advised nulliparous women to complete their evaluation by performing hysteroscopy. It provides reliable information for the anatomical status of the cervix, tubal ostia and, especially, uterine cavity. In cases of infertility or recurrent pregnancy losses, the dilemma is whether to proceed with the resection of the uterine septum in combination with resection of vaginal one.

Key Messages: A complete uterine septum with double functional cervix may have a wide spectrum of reproductive outcomes; The association of uterine anomalies with the woman’s fertility status remains controversial; Patients with septate uterus and history of infertility or poor pregnancy outcome should complete their investigation and proceed with resection of septum.

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