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Telavancin Activity Against a Global Collection of Staphylococcus aureus Clinical Isolates (2013–2015)

Pfaller MA, Mendes RE*, Sader HS, Duncan LR, Castanheira M, Shortridge D and Flamm RK

Telavancin had MIC₅₀, MIC₉₀, and MIC₁₀₀ values of 0.03, 0.06, and 0.12 μg/mL, respectively, against methicillinsusceptible (MSSA), methicillin-resistant (MRSA), and MRSA multidrug-resistant (MDR) subsets of Staphylococcus aureus. Isolates with elevated vancomycin MIC values (2 μg/mL) resulted in a telavancin MIC₅₀ (0.06 μg/mL) 2-fold higher than isolates with lower vancomycin MIC results (telavancin MIC₅₀, 0.03 μg/mL). However, telavancin had MIC₉₀ and MIC₁₀₀ results of 0.06 and 0.12 μg/mL (100% susceptible), respectively, regardless of methicillin-resistance phenotype.